CGU-10 2007_0418test0373
CGU 2008 DSCF9578
CGU--1-2 2007_0208test0480
CGU 2008 DSCF9601
CGU-12 2007_0418test0463
CGU-4 2007_0101test0432
201409DSCF1050
擷取
擷取1
123
DSCF9554
癌症及遺傳疾病的成因與治療机制是我們的研究興趣。運用基因生物學 (genomics) 及生物資訊 (bioinformatics) 的組合,我們可以藉由細胞及動物操作,有效地窺探人類的癌症及遺傳疾病的生物學基礎,最終期望能提供研發新藥參考及臨床醫學對策。目前較投入的研究涵蓋:(I) 抗藥基因與標靶治療 (Chemoresistance gene & target therapy),(II) 幹細胞、分化與發育 (Stem cells, differentiation & development),(III) 腫瘤微環境基因與病理 (Genetics and pathogenesis of tumor microenvironment)。
The New Publication 
Identification of the β-catenin/JNK/prothymosin-alpha axis as a novel target of sorafenib in hepatocellular carcinoma cells. Oncotarget 6: 38999-39017, 2015 (Lin, Y.-T. and Chao, C.C.-K.)(PubMed)
 
Oncogenic c-Myc and prothymosin-alpha protect hepatocellular carcinoma cells against sorafenib-induced apoptosis. Biochem. Pharmacol. 93: 110-124, 2015 (Lin, Y.-T., Lu, H.-P. and Chao, C.C.-K.)(PubMed)
Inhibition of JNK and prothymosin-alpha sensitizes hepatocellular carcinoma cells to cisplatin. Biochem. Pharmacol. 122: 80-89, 2016 (Lin, Y.-T., Liu, Y.-C. and Chao, C.C.-K.)(PubMed)
Growth-arrest-specific 7 gene regulates neural crest formation and craniofacial development in zebrafish. Stem Cells Dev. 24: 2943-2951, 2015 (Hung, F.-C.*, Shih, H.-Y.*, Cheng, Y.-C. and Chao, C.C.-K.)(PubMed)
Integrative transcriptomics-based identification of cryptic drivers of taxol-resistance genes in ovarian carcinoma cells: analysis of the androgen receptor. Oncotarget, 6: 27065-27082, 2015 (Sun, N.-K.*, Huang, S.-L.*, Lu, H.-P., Chang, T.-C. and Chao, C.C.-K.)(PubMed)
TLR4 and NFkB signaling is critical for taxol resistance in ovarian carcinoma cells. J. Cell. Physiol., 2017 Aug 3;1–13. https://doi.org/10.1002/jcp.26125 (Sun, N.-K., Huang, S.-L., Chang, T.-C. and Chao, C.C.-K.)(PudMed)
CITED2 silencing sensitizes cancer cells to cisplatin by inhibiting p53 trans-activation and chromatin relaxation on the ERCC1 DNA repair gene. Nucleic Acids Res. 43: 10760-10781, 2015 (Liu, Y.-C., Chang, P.-Y. and Chao, C.C.-K.)(PubMed)
Mechanisms of p53 degradation. Clinica Chimica Acta 438: 139-147, 2015 (Chao, C.C.-K.) [invited review](PubMed
Inhibition of apoptosis by oncogenic hepatitis B virus X protein: Implications for the treatment of hepatocellular carcinoma. World J. Hepatol. 8(25): 1061-1066, 2016 (Chao, C.C.-K.) [invited review](PubMed)
Spontaneous metastases in immunocompetent mice harboring a primary tumor driven by oncogene latent membrane protein 1 from Epstein-Barr virus. Biomed. J. 39: 261-271, 2016 (Chang, P.-Y.#, Huang, Y. #, Hung, T.Y., Chong, K.Y., Chang, Y.S., Chao, C.C.-K.* and Chow, K.P.N.*)(*co-correspondence)(PubMed)
Historical figures
趙清貴 教授
Chuck Chao, Ph.D.
Pair-1 Luria & Delbruck
Pair-1 Luria & Delbruck

press to zoom
Pair-2 130628164406-watson-crick-cambridge-story-top
Pair-2 130628164406-watson-crick-cambridge-story-top

press to zoom
M-4 MH-1 SARS inhibited Singapore Biopolis
M-4 MH-1 SARS inhibited Singapore Biopolis

press to zoom
Pair-1 Luria & Delbruck
Pair-1 Luria & Delbruck

press to zoom
1/11