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  1. Wu, Z.-Z., Lu, H.-P. and Chao, C.C.-K. Identification and functional analysis of genes which confer resistance to cisplatin in tumor cells. Biochem. Pharmacol. 80: 262-276, 2010
  2. Sun, N.-K.*, Sun, C.-L.*, Lin, C.-H., Pai, L.-M. and Chao, C.C.-K. Damaged DNA-binding protein 2 (DDB2) protects against UV irradiation in human cells and Drosophila. J. Biomed. Sci., 17: 27, 2010 (DOI: 10.1186/1423-0127-17-27) (*equal contribution)
  3. Wu, Z.-Z. and Chao, C.C.-K. Knockdown of NAPA using short-hairpin RNA sensitizes cancer cells to cisplatin: implications to overcome chemoresistance. Biochem. Pharmacol. 80: 827-837, 2010
  4. Kuo, T.-C. and Chao, C.C.-K. Hepatitis B virus X protein prevents apoptosis of hepatocellular carcinoma cells by upregulating SATB1 and HURP expression. Biochem. Pharmacol. 80: 1093-1102, 2010
  5. Wu, Z.-Z.. Sun, N.-K. and Chao, C.C.-K. Knockdown of CITED2 using short-hairpin RNA sensitizes cancer cells to cisplatin through stabilization of p53 and enhancement of p53-dependent apoptosis. J. Cell. Physiol. 226:2415-2428, 2011 (online DOI: 10.1002/jcp.20589, 2010)
  6. Chao, C.C.-K. A search for the genes involved in resistance to cisplatin chemotherapy: Review of the experimental evidence. Curr. Top. Pharmacol. 14: 47-54, 2011 [invited review]
  7. Kuo, T.-C.*, Lu, H.-P.* and Chao, C.C.-K. The tyrosine kinase inhibitor sorafenib sensitizes hepatocellular carcinoma cells to taxol by suppressing the HURP protein.  Biochem. Pharmacol. 82: 184-194, 2011 (*equal contribution)
  8. Chao, C.C.-K. The role of DDB2 in the regulation of cell survival and apoptosis following DNA damage (a mini-review). In DNA Repair / Book 4 (ed., Kruman, I.), InTech: 2011 pp. 45-56 (ISBN 978-953-307-697-3) [invited review]
  9. Wu, Z.-Z., Sun, N.-K., Chien, K.-Y. and Chao, C.C.-K. Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation. Biochem. Pharmacol. 82: 1630-1640, 2011
  10. Wu, Z-Z*, Chow, K-PN*, Kuo, T-C, Chang, Y-S, Chao, CC-K. Latent membrane protein 1 of Epstein–Barr virus sensitizes cancer cells to cisplatin by enhancing NF-kB p50 homodimer formation and downregulating NAPA expression. Biochem. Pharmacol. 82: 1860-1872, 2011 (*equal contribution)
  11. Kuo, T.-C., Chang, P.-Y., Huang, S.-F., Chou, C.-K. and Chao, C.C.-K. Knockdown of HURP inhibits the proliferation of hepacellular carcinoma cells via downregulation of gankyrin and accumulation of p53. Biochem. Pharmacol. 83: 758-768, 2012
  12. Chao, C.C.-K. Adapting new ways to escape attacks by anti-cancer drugs: Epigenetic changes and alternative splicing. Adaptive Medicine 4: 64-68, 2012 [invited review]
  13. Sun, N.-K., Huang, S.-L., Chien, K.-Y. and Chao, C.C.-K. Golgi-SNARE GS28 potentiates cisplatin-induced apoptosis by forming GS28/MDM2/p53 complexes and by preventing the ubiquitination and degradation of p53. Biochem J. 444: 303-314, 2012
  14. Lu, H.-P. and Chao, C.C.-K. Cancer cells acquire resistance to anticancer drugs: An update. Biomed. J. 35: 464-472, 2012  [invited review]
  15. Sun, N.-K., Huang, S.-L., Chang, T.-C. and Chao, C.C.-K. Sorafenib induces endometrial carcinoma apoptosis by inhibiting Elk-1-dependent Mcl-1 transcription and inducing Akt/GSK3b-dependent protein degradation. J. Cell. Biochem. 114: 1819-1831, 2013
  16. Chang, P.-Y.*, Wu, Z.-Z.*, Sun, N.-K. and Chao, C.C.-K. EBV-encoded LMP-1 sensitizes nasopharyngeal carcinoma cells to genotoxic drugs by down-regulating Cabin1 expression. J. Cell. Physiol. 229: 309-322, 2014 [online doi: 10.1002/jcp.24448, 2013] (*equal contribution)
  17. Sun, N.-K.*, Huang, S.-L.*, Chang, P.-Y., Lu, H.-P. and Chao, C.C.-K. Transcriptomic profiling of taxol-resistant ovarian cancer cells identifies FKBP5 and the androgen receptor as critical markers of chemotherapeutic response. Oncotarget 5: 11939-11956, 2014 (*equal contribution)
  18. Huang, S.-L. and Chao, C.C.-K. Linking immunophilin FKBP5 to taxol resistance in ovarian cancer. Cancer Cell & Microenviron. 2015; 2: e692. doi: 10.14800/ccm.692 [invited research highlight]
  19. Chao, C.C.-K. Mechanisms of p53 degradation. Clinica Chemica Acta 438: 139-147, 2015 [online 2014; doi: 10.1016/j.cca.2014.08.015] (PubMed) [invited review](PubMed)
  20. Lin, Y.-T., Lu, H.-P. and Chao, C.C.-K. Oncogenic c-Myc and prothymosin-alpha protect hepatocellular carcinoma cells against sorafenib-induced apoptosis. Biochem. Pharmacol.  93: 110-124, 2015 [online 2014 doi: 10.1016/j.bcp.2014.10.012]
  21. Lin, Y.-T. and Chao, C.C.-K. Sorafenib induces apoptosis in hepatocellular carcinoma cells by inhibiting c-Myc and prothymosin-alpha. Cancer Cell & Microenviron. 2015; 2: e788; doi: 10.14800/ccm.788 [invited research highlight]
  22. Huang, S.-L. and Chao, C.C.-K. Silencing of taxol-sensitizer genes in cancer cells: Lack of sensitization effects. Cancers 7: 1052-1071, 2015; doi:10.3390/cancers7020824 (special issue - Cancer Cell Proliferation) [invited article]
  23. Ho, C.-H., Hsu, J.-L., Liu, S.-P., Hsu, L.-C., Chang, W.-L. Chao, C.C.-K., Guh, J.-H. Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathway. Prostate 75(13): 1454-1466, 2015
  24. Sun, N.-K.*, Huang, S.-L.*, Lu, H.-P., Chang, T.-C. and Chao, C.C.-K. Integrative transcriptomics-based identification of cryptic drivers of taxol-resistance genes in ovarian carcinoma cells: analysis of the androgen receptor. Oncotarget 6: 27065-27082, 2015; doi: 10.18632/oncotarget.4824 (*equal contribution)
  25. Liu, Y.-C., Chang, P.-Y. and Chao, C.C.-K. CITED2 silencing sensitizes cancer cells to cisplatin by inhibiting p53 trans-activation and chromatin relaxation on the ERCC1 DNA repair gene. Nucleic Acids Res. 43: 10760-10781, 2015;  doi: 10.1093/nar/gkv934
  26. Lin, Y.-T. and Chao, C.C.-K. Identification of the β-catenin/JNK/prothymosin-alpha axis as a novel target of sorafenib in hepatocellular carcinoma cells. Oncotarget 6: 38999-39017, 2015; doi: 10.18632/oncotarget.5738
  27. Chang, P.-Y.#, Huang, Y. #, Hung, T.Y., Chong, K.Y., Chang, Y.S., Chao, C.C.-K.* and Chow, K.P.N.* Spontaneous metastases in immunocompetent mice harboring a primary tumor driven by oncogene latent membrane protein 1 from Epstein-Barr virus. Biomed. J. 39: 261-271, 2016 (#equal contribution; *co-correspondence)(PubMed)
  28. Chao, C.C.-K.  Inhibition of apoptosis by oncogenic hepatitis B virus X protein: Implications for the treatment of hepatocellular carcinoma. World J. Hepatol. 8(25): 1061-1066, 2016 (invited review)(PubMed)
  29. Lin, Y.-T., Liu, Y.-C. and Chao, C.C.-K. Inhibition of JNK and prothymosin-alpha sensitizes hepatocellular carcinoma cells to cisplatin. Biochem. Pharmacol. 122: 80-89, 2016 (PubMed)
  30. Sun, N.-K., Huang, S.-L., Chang, T.-C. and Chao, C.C.-K. TLR4 and NFkB signaling is critical for taxol resistance in ovarian carcinoma cells. J. Cell. Physiol., 2017 Aug 3;1–13. https://doi.org/10.1002/jcp.26125 (PudMed)

近期學術著作

抗藥基因與標靶治療 (Chemoresistance gene & target therapy)

幹細胞、分化與發育 (Stem cells, differentiation & development)

  1. Ju, Y.T., Chang, A.C.Y., She, B.-R., Tsau, M.-L., Hwang, H.-M., Chao, C.C.-K., Cohen, S.N. and Lin-Chao, S. Gas7, a mouse novel gene expressed preferentially during growth arrest of fibroblasts and in terminally differentiated Purkinje neurons is required for neurite formation. Proc. Natl. Acad. Sci. USA, 95: 11423-11428, 1998
  2. Chao, C.C.-K., Su, L.-J., Sun, N.-K., Ju, Y.-T., Lih, C.J. and Lin-Chao, S. Involvement of Gas7 in nerve growth factor-independent and dependent cell processes in PC12 cells. J. Neurosci. Res. 74: 248-254, 2003
  3. Chang, P.-Y., Kuo, J.-T., Lin-Chao, S. and Chao, C.C.-K. Identification of rat Gas7 isoforms differentially expressed in brain and regulated after kainate-induced neuronal injury. J. Neurosci. Res. 79: 788-797, 2005
  4. Chao, C.C.-K., Chang, P.-Y. and Lu, H.-P. Human Gas7 isoforms homologous to mouse transcripts differentially induce neurite outgrowth. J. Neurosci. Res. 81: 153-162, 2005
  5. Chang, Y, Ueng, S.W.N., Lin-Chao, S. and Chao, C.C.-K. Involvement of Gas7 along the ERK 1/2 MAP kinase and SOX9 pathway in chondrogenesis of human marrow derived mesenchymal stem cells. Osteoarthritis Cartilage 16: 1403-1412, 2008
  6. Chang, Y, Hsieh, P.-H. and Chao, C.C.-K. The efficiency of using density gradient media in isolation of marrow-derived human mesenchymal stem cells with osteogenic potential. Chang Gung Med. J. 32: 264-275, 2009
  7. Huang, B.-T., Su, W.B., Chang, P.-Y., Su, C.-H., Chao, C.C.-K. and Lin-Chao, S. Gas7 is involved in regulation of endplate structure and muscle fiber type determination. Mech. Develop. 126: S137-S138, 2009 (DOI: 10.1016/j.mod.2009.06.287)
  8. Hung, F.-C. and Chao, C.C.-K. Knockdown of growth-arrest-specific 7b gene (Gas7b) using short-hairpin RNA desensitizes neuroblastoma cells to cisplatin: implications to prevent apoptosis of neurons. J. Neurosci. Res. 88: 3578-3587, 2010
  9. Hung, F.-C., Chang, Y., Lin-Chao, S  and Chao, C.C.-K. Gas7 mediates the differentiation of human bone marrow-derived mesenchymal stem cells into functional osteoblasts by enhancing Runx2-dependent gene expression. J. Orthopaedic Res. 29: 1528-1535, 2011
  10. Huang, B.-T., Chang, P.-Y., Su, C.-H., Chao, C.C.-K. and Lin-Chao, S. Deficiency of Gas7 in mice reveals motor coordination defects due to abnormal motor neuron function and muscle fiber composition during aging. PLoS ONE  7(5): e37702. doi:10.1371/journal.pone.0037702, 2012
  11. Hung, F.-C., Cheng, Y.-C., Sun, N.-K. and Chao, C.C.-K. Identification and characterization of zebrafish gas7 gene in early development. J. Neurosci. Res. 91: 51-61, 2013 [online doi: 10.1002/jnr.23145, 2012]
  12. Chao, C.C.-K, Hung, F.-C. and Chao, J.J. Gas7 is required for mesenchymal stem cell-derived bone development. Stem Cells Int. vol. 2013, Article ID 137010, 6 pages, 2013. doi:10.1155/2013/137010 [invited review](PubMed)
  13. Hung, F.-C.*, Shih, H.-Y.*, Cheng, Y.-C. and Chao, C.C.-K. Growth-arrest-specific 7 gene regulates neural crest formation and craniofacial development in zebrafish. Stem Cells Dev. 24: 2943-2951, 2015; doi: 10.1089/scd.2015.0146 (*equal contribution)(PubMed)
  14. Hung, F.-C. and Chao, C.C.-K. Gas7 deficiency attenuates MyoD transactivity, impairs myoblast differentiation and potentiates muscle atrophy. 2016 (in preparation)
  15. Chang, P.-Y.*, Hung, F.-C.*, Tu, S.-J., Lin-Chao, S. and Chao, C.C.-K. Disruption of gas7 gene expression impairs osteogenic differentiation of mouse mesenchymal stem cells and osteoblasts associated with reduction in the tibia trabecular bone of older mice. 2016 (in preparation) (*equal contribution)
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